Research Library

Supplement Research

Evidence-graded guides for common supplements. Each article includes evidence level, study count, proposed mechanisms, and structured summaries.

50+
Supplement topics
◐ Moderate
Magnesium for Sleep: Research-Based Evidence
8 RCTs on magnesium glycinate and citrate for sleep onset, quality, and duration in adults. Mechanisms include GABA modulation and cortisol reduction.
⭐ Strong
Vitamin D & Immunity: What the Research Shows
14 RCTs confirm Vitamin D3's role in innate and adaptive immune function. Deficiency is widespread and strongly linked to increased infection susceptibility.
⭐ Strong
Omega-3 Fatty Acids & Heart Health
Meta-analysis summary on EPA/DHA's effects on triglycerides, inflammation markers, and cardiovascular event risk reduction.
◐ Moderate
Creatine for Brain Health & Cognitive Function
Beyond muscle: emerging evidence on creatine's role in cognitive performance, mental fatigue, and neuroprotection in aging adults.
◐ Moderate
Probiotics: Gut-Brain Axis & Mood
What research says about probiotic strains, the gut-brain axis, and their downstream effects on mood, anxiety, and immune health.
⭐ Strong
Vitamin B12: Deficiency, Energy & Neurological Health
Strong evidence for B12's role in red blood cell formation, neurological function, and fatigue reduction in deficient populations.
⭐ Strong
Iron Supplementation & Fatigue
Comprehensive review of iron deficiency anemia, its effects on energy and cognition, and evidence-based supplementation protocols.
◐ Moderate
Ashwagandha for Stress & Cortisol
A review of clinical evidence on ashwagandha (KSM-66, Sensoril) for cortisol reduction, stress perception, and sleep quality in adults.
⭐ Strong
Zinc & Immune Function
Zinc's essential role in immune cell development and function. Evidence on deficiency prevalence, supplementation protocols, and upper limits.
⭐ Moderate-Strong
Collagen Peptides for Skin, Joints & Gut Health
The evidence on hydrolyzed collagen — skin elasticity, joint pain, bone density, gut barrier support, types I/II/III, marine vs bovine, and optimal dosing protocols.
🔬 Moderate
NMN & NAD+: Longevity, Energy & Cellular Aging
NAD+ declines 40–50% by age 60. NMN supplementation raises blood NAD+, improves muscle insulin sensitivity, and aerobic capacity. Human trials, mechanisms, and NMN vs NR comparison.
🔬 Moderate
Lion's Mane Mushroom for Cognitive Function
The nootropic mushroom with RCT evidence for MCI and acute cognitive performance. Hericenones and erinacines stimulate NGF and BDNF. Product quality guide and dosing protocol.
⭐ Moderate-Strong
Rhodiola Rosea for Stress, Fatigue & Cognitive Performance
The most clinically validated adaptogen for burnout and mental fatigue. Multiple RCTs including a 480-person trial. Compared to ashwagandha — mechanisms, dosing, and when to use each.
⭐ Moderate-Strong
Urolithin A: Mitophagy, Muscle Health & Longevity
The only food-derived compound shown to activate mitophagy in humans. Published in Nature Metabolism and Nature Aging. Muscle strength +12% in older adults. 30–40% of people can't produce it from diet.